Erik C. Andersen
Humans differ in their susceptibilities to cancer, diabetes, and other common diseases because of each individual's unique genetic makeup and the effects of their particular environment. The Andersen laboratory uses classical, quantitative, and molecular genetics in the roundworm Caenorhabditis elegans to identify the genes that vary within populations to cause differences in disease susceptibilities. C. elegans is a powerful experimental platform for many reasons, including its high level of conservation with humans, its ease of manipulation, a powerful genetic and genomic toolkit, a large wild strain collection that contains variation comparable to that of humans, and the ability to connect gene function to tissues and cells in an intact organism. In addition to genetics, we use new sequencing technologies, high-throughput phenotyping assays, and diverse genomic tools to determine the molecular mechanisms for how genetic variation causes phenotypic differences.
The Genetic Basis of Natural Variation in Caenorhabditis elegans Telomere Length. Cook DE, Zdraljevic S, Tanny RE, Seo B, Riccardi DD, Noble LM, Rockman MV, Alkema MJ, Braendle C, Kammenga JE, Wang J, Kruglyak L, Félix M-A, Lee J, and Andersen EC. Genetics. 2016 September 1;204(1):371-383.
Prospects and challenges of CRISPR/Cas genome editing for the study and control of neglected vector-borne nematode diseases. Zamanian M and Andersen EC. FEBS Journal. 2016 September;283(17):3204-3221.
Mutation Is a Sufficient and Robust Predictor of Genetic Variation for Mitotic Spindle Traits in Caenorhabditis elegans. Farhadifar R, Ponciano JM, Andersen EC, Needleman DJ, and Baer CF. Genetics. 2016 August 1;203(4):1859-1870.
Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans. Large EE, Xu W, Zhao Y, Brady SC, Long L, Butcher RA, Andersen EC, and McGrath PT. PLoS Genetics. 2016 July 28;12(7):e1006219.
Remarkably Divergent Regions Punctuate the Genome Assembly of the Caenorhabditis elegans Hawaiian Strain CB4856. Thompson OA, Snoek LB, Nijveen H, Sterken MG, Volkers RJM, Brenchley R, van't Hof A, Bevers RPJ, Cossins AR, Yanai I, Hajnal A, Schmid T, Perkins JD, Spencer D, Kruglyak L, Andersen EC, Moerman DG, Hillier LW, Kammenga JE, and Waterston RH. Genetics. 2015 July 1;200(3):975-989.
A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains. Andersen EC, Shimko TC, Crissman JR, Ghosh R, Bloom JS, Seidel HS, Gerke JP, and Kruglyak L. G3. 2015 May 1;5(5):911-920.
The laboratory domestication of Caenorhabditis elegans. Sterken MG, Snoek LB, Kammenga JE, and Andersen EC. Trends in Genetics. 2015 May;31(5):224-231.
Scaling, Selection, and Evolutionary Dynamics of the Mitotic Spindle. Farhadifar R, Baer CF, Valfort A-C, Andersen EC, Müller-Reichert T, Delattre M, and Needleman DJ. Current Biology. 2015 March 16;25(6):732-740.
A Wild C. Elegans Strain Has Enhanced Epithelial Immunity to a Natural Microsporidian Parasite. Balla KM, Andersen EC, Kruglyak L, and Troemel ER. PLoS Pathogens. 2015 February 13;11(2):e1004583.
The red death meets the abdominal bristle: Polygenic mutation for susceptibility to a bacterial pathogen in Caenorhabditis elegans. Etienne V, Andersen EC, Ponciano JM, Blanton D, Cadavid A, Joyner-Matos J, Matsuba C, Tabman B, and Baer CF. Evolution. 2015 February;69(2):508-519.
COPASutils: An R Package for Reading, Processing, and Visualizing Data from COPAS Large-Particle Flow Cytometers. Shimko TC and Andersen EC. PLoS ONE. 2014 October 20;9(10):e111090.
A Variant in the Neuropeptide Receptor npr-1 is a Major Determinant of Caenorhabditis elegans Growth and Physiology. Andersen EC, Bloom JS, Gerke JP, and Kruglyak L. PLoS Genetics. 2014 February 27;10(2):e1004156.
Species richness, distribution and genetic diversity of Caenorhabditis nematodes in a remote tropical rainforest. Félix M-A, Jovelin R, Ferrari C, Han S, Cho YR, Andersen EC, Cutter AD, and Braendle C. BMC Evolutionary Biology. 2013 January 12;13:10.
Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity. Andersen EC, Gerke JP, Shapiro JA, Crissman JR, Ghosh R, Bloom JS, Félix M-A, and Kruglyak L. Nature Genetics. 2012 March;44(3):285-290.
Natural Variation in a Chloride Channel Subunit Confers Avermectin Resistance in C. elegans. Ghosh R, Andersen EC, Shapiro JA, Gerke JP, and Kruglyak L. Science. 2012 February 3;335(6068):574-578.
View all publications by Erik C. Andersen listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.