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Vadim Backman

Vadim Backman

Walter Dill Scott Professor
Biomedical Engineering
PhD, Harvard University - MIT

Email: v-backman@northwestern.edu
Phone: (847) 491-3536
Fax: (847) 491-4928
Room: Silverman 3627


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Research Interests

The main direction of our lab is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease, and characterization of biological and bioengineered tissue. Our research spans from basic physics of light-tissue interaction to new technology development to the development of clinical instrumentation and to large-scale clinical trials.

Selected Publications

The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene Expression. Almassalha LM, Tiwari A, Ruhoff PT, Stypula-Cyrus Y, Cherkezyan L, Matsuda H, Dela Cruz MA, Chandler JE, White C, Maneval C, Subramanian H, Szleifer I, Roy HK, and Backman V. Scientific Reports. 2017 January 24;7:41061.

Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopy. Almassalha LM, Bauer GM, Chandler JE, Gladstein S, Cherkezyan L, Stypula-Cyrus Y, Weinberg S, Zhang D, Ruhoff PT, Roy HK, Subramanian H, Chandel NS, Szleifer I, and Backman V. PNAS. 2016 October 18;113(42):E6372-E6381.

Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography. Spicer GLC, Azarin SM, Yi J, Young ST, Ellis R, Bauer GM, Shea LD, and Backman V. Physics in Medicine and Biology. 2016 October 7;61(19):6892-6904.

Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo. Rao SS, Bushnell GG, Azarin SM, Spicer G, Aguado BA, Stoehr JR, Jiang EJ, Backman V, Shea LD, and Jeruss JS. Cancer Research. 2016 September 15;76(18):5209-5218.

Superresolution intrinsic fluorescence imaging of chromatin utilizing native, unmodified nucleic acids for contrast. Dong B, Almassalha LM, Stypula-Cyrus Y, Urban BE, Chandler JE, Nguyen T-Q, Sun C, Zhang HF, and Backman V. PNAS. 2016 August 30;113(35):9716-9721.

Super-resolution spectroscopic microscopy via photon localization. Dong B, Almassalha L, Urban BE, Nguyen T-Q, Khuon S, Chew T-L, Backman V, Sun C, and Zhang HF. Nature Communications. 2016 July 25;7:12290.

Subsurface Super-resolution Imaging of Unstained Polymer Nanostructures. Urban BE, Dong B, Nguyen T-Q, Backman V, Sun C, and Zhang HF. Scientific Reports. 2016 June 29;6:28156.

Finite-difference time-domain-based optical microscopy simulation of dispersive media facilitates the development of optical imaging techniques. Zhang D, Capoglu I, Li Y, Cherkezyan L, Chandler J, Spicer G, Subramanian H, Taflove A, and Backman V. Journal of Biomedical Optics. 2016 June 10;21(6):065004.

Skeletal light-scattering accelerates bleaching response in reef-building corals. Swain TD, DuBois E, Gomes A, Stoyneva VP, Radosevich AJ, Henss J, Wagner ME, Derbas J, Grooms HW, Velazquez EM, Traub J, Kennedy BJ, Grigorescu AA, Westneat MW, Sanborn K, Levine S, Schick M, Parsons G, Biggs BC, Rogers JD, Backman V, and Marcelino LA. BMC Ecology. 2016 March 21;16:10.

Nanoscale refractive index fluctuations detected via sparse spectral microscopy. Chandler JE, Cherkezyan L, Subramanian H, and Backman V. Biomedical Optics Express. 2016 March 1;7(3):883-893.

Reconstruction of explicit structural properties at the nanoscale via spectroscopic microscopy. Cherkezyan L, Zhang D, Subramanian H, Taflove A, and Backman V. Journal of Biomedical Optics. 2016 February 17;21(2):025007.

Fractal Characterization of Chromatin Decompaction in Live Cells. Yi J, Stypula-Cyrus Y, Blaha CS, Roy HK, and Backman V. Biophysical Journal. 2015 December 1;109(11):2218-2226.

Spectroscopic microscopy can quantify the statistics of subdiffractional refractive-index fluctuations in media with random rough surfaces. Zhang D, Cherkezyan L, Capoglu I, Subramanian H, Chandler J, Thompson S, Taflove A, and Backman V. Optics Letters. 2015 November 1;40(21):4931-4934.

Rectal Optical Markers for In vivo Risk Stratification of Premalignant Colorectal Lesions. Radosevich AJ, Mutyal NN, Eshein A, Nguyen T-Q, Gould B, Rogers JD, Goldberg MJ, Bianchi LK, Yen EF, Konda V, Rex DK, Van Dam J, Backman V, and Roy HK. Clinical Cancer Research. 2015 October 1;21(19):4347-4355.

Visible light optical coherence tomography measures retinal oxygen metabolic response to systemic oxygenation. Yi J, Liu W, Chen S, Backman V, Sheibani N, Sorenson CM, Fawzi AA, Linsenmeier RA, and Zhang HF. Light: Science & Applications. 2015 September 25;4:e334.

In vivo capture and label-free detection of early metastatic cells. Azarin SM, Yi J, Gower RM, Aguado BA, Sullivan ME, Goodman AG, Jiang EJ, Rao SS, Ren Y, Tucker SL, Backman V, Jeruss JS, and Shea LD. Nature Communications. 2015 September 8;6:8094.

In Vivo Risk Analysis of Pancreatic Cancer Through Optical Characterization of Duodenal Mucosa. Mutyal NN, Radosevich AJ, Bajaj S, Konda V, Siddiqui UD, Waxman I, Goldberg MJ, Rogers JD, Gould B, Eshein A, Upadhye S, Koons A, Gonzalez-Haba Ruiz M, Roy HK, and Backman V. Pancreas. 2015 July;44(5):735-741.

Super-resolution two-photon microscopy via scanning patterned illumination. Urban BE, Yi J, Chen S, Dong B, Zhu Y, DeVries SH, Backman V, and Zhang HF. Physical Review E. 2015 April 7;91(4):042703.

View all publications by Vadim Backman listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.