Over the past decade, two startling health statistics have captured widespread public attention: first, that all children born in the year 2000 face a one-in-three chance of developing diabetes during their lifetime; second, that nearly one-third of the US population is overweight or obese.
Although sedentary habits and high fat diet are the most recognized factors in this epidemic, new evidence from both clinical studies in humans and experimental models has pinpointed a role for disruption in the circadian system and sleep in obesity and diabetes. Our focus is to dissect the molecular basis underlying metabolic and energy disorders in models of circadian disruption using a range of approaches from genetics, biochemistry, cell biology and physiology.
Circadian Clock Interaction with HIF1α Mediates Oxygenic Metabolism and Anaerobic Glycolysis in Skeletal Muscle. Peek CB, Levine DC, Cedernaes J, Taguchi A, Kobayashi Y, Tsai SJ, Bonar NA, McNulty MR, Ramsey KM, and Bass J. Cell Metabolism. 2017 January 10;25(1):86-92.
Circadian Transcription from Beta Cell Function to Diabetes Pathophysiology. Perelis M, Ramsey KM, Marcheva B, and Bass J. Journal of Biological Rhythms. 2016 August;31(4):323-336.
Neural circuits: Decoding obesity in the brainstem. Cedernaes J and Bass J. eLife. 2016 May 9;5:e16393.
Targeting Time in Metabolic Therapeutics. Bass J. Cell Metabolism. 2016 April 12;23(4):575-577.
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion. Perelis M, Marcheva B, Ramsey KM, Schipma MJ, Hutchison AL, Taguchi A, Peek CB, Hong H, Huang W, Omura C, Allred AL, Bradfield CA, Dinner AR, Barish GD, and Bass J. Science. 2015 November 6;350(6261):aac4250.
Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice. Peek CB, Affinati AH, Ramsey KM, Kuo H-Y, Yu W, Sena LA, Ilkayeva O, Marcheva B, Kobayashi Y, Omura C, Levine DC, Bacsik DJ, Gius D, Newgard CB, Goetzman E, Chandel NS, Denu JM, Mrksich M, and Bass J. Science. 2013 November 1;342(6158):1243417.
Forever (FGF) 21. Bass J. Nature Medicine. 2013 September;19(9):1090-1092.
Usf1, a suppressor of the circadian Clock mutant, reveals the nature of the DNA-binding of the CLOCK:BMAL1 complex in mice. Shimomura K, Kumar V, Koike N, Kim T-K, Chong J, Buhr ED, Whiteley AR, Low SS, Omura C, Fenner D, Owens JR, Richards M, Yoo S-H, Hong H-K, Vitaterna MH, Bass J, Pletcher MT, Wiltshire T, Hogenesch J, Lowrey PL, and Takahashi JS. eLife. 2013 April 9;2:e00426.
Circadian Clocks and Metabolism. Marcheva B, Ramsey KM, Peek CB, Affinati A, Maury E, and Bass J. Handbook of Experimental Pharmacology. 2013;217:127-155.
Circadian topology of metabolism. Bass J. Nature. 2012 November 15;491(7424):348-356.
Nutrient sensing and the circadian clock. Peek CB, Ramsey KM, Marcheva B, and Bass J. Trends in Endocrinology & Metabolism. 2012 July;23(7):312-318.
Drug discovery: Time in a bottle. Bass J. Nature. 2012 May 3;485(7396):45-46.
Klf15 Orchestrates Circadian Nitrogen Homeostasis. Jeyaraj D, Scheer FAJL, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee H, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, and Jain MK. Cell Metabolism. 2012 March 7;15(3):311-323.
Physiology: On time metabolism. Bass J. Nature. 2011 December 22;480(7378):466-467.
Generation of N-Ethyl-N-nitrosourea (ENU) Diabetes Models in Mice Demonstrates Genotype-specific Action of Glucokinase Activators. Fenner D, Odili S, Hong H-K, Kobayashi Y, Kohsaka A, Siepka SM, Vitaterna MH, Chen P, Zelent B, Grimsby J, Takahashi JS, Matschinsky FM, and Bass J. Journal of Biological Chemistry. 2011 November 11;286(45):39560-39572.
View all publications by Joseph Bass listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.