Faculty
Joseph Bass
Assistant Professor
Medicine, Feinberg School of Medicine; NBP
MD/PhD, Medical College of Pennsylvania
Email: j-bass@northwestern.edu
Phone: (847) 467-5973
Fax: (847) 491-4400
Room: Pancoe Rm 4-405
Research Interests
Over the past decade, two startling health statistics have captured widespread public attention: first, that all children born in the year 2000 face a one in three chance of developing diabetes during their lifetime and second, that nearly one third of the US population is overweight or obese. Although sedentary habits, high fat diet, and altered sleep-wake patterns have been implicated, how environmental and genetic factors interact in the development of diabetes and obesity is still uncertain. Recent evidence suggests that pathways within the brain also play a critical role in the regulation of organismal energy balance and in peripheral fuel utilization. Our group studies the molecular links between neural circuits coordinating feeding behavior, sleep and wakefulness with systems important in peripheral fuel utilization, including the insulin-signaling pathway. There are two overarching themes in our research:
1-Transcriptional and posttranslational interactions between circadian and metabolic gene networks in the development of diabetes and obesity
2-Genetic and genomic analysis of glucose metabolism and insulin resistance
learn more about these projects on the Bass Lab website.
Selected Publications
Ramsey KM, Yoshino J, Brace CS, Abrassart D, Kobayashi Y, Marcheva B, Hong HK, Chong JL, Buhr ED, Lee C, Takahashi JS, Imai SI, Bass J. Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis. Science. 2009 Mar 19. [Epub ahead of print]
Chen WS, Peng XD, Wang Y, Xu PZ, Chen ML, Luo Y, Jeon SM, Coleman K, Haschek WM, Bass J, Philipson LH, Hay N. Leptin deficiency and beta-cell dysfunction underlie type 2 diabetes in compound Akt knockout mice. Mol Cell Biol. 2009 Mar 16. [Epub ahead of print]
Obeying the clock yields benefits for metabolism. Ramsey KM, Bass J Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4069-70. Epub 2009 Mar 10. Review.
Kohsaka A, Laposky AD, Ramsey KM, Estrada C, Joshu C, Kobayashi Y, Turek FW, Bass J. High-fat diet disrupts behavioral and molecular circadian rhythms in mice. Cell Metab. 2007 Nov;6(5):414-21.
Laposky AD, Bass J, Kohsaka A, Turek FW. Sleep and circadian rhythms: key components in the regulation of energy metabolism. FEBS Lett. 2008 Jan 9;582(1):142-51. Epub 2007 Aug 14. Review.
Ramos RR, Swanson AJ, Bass J. Calreticulin and Hsp90 stabilize the human insulin receptor and promote its mobility in the endoplasmic reticulum. Proc Natl Acad Sci U S A. 2007 Jun 19;104(25):10470-5. Epub 2007 Jun 11.
Ramsey KM, Bass J. Lean gene and the clock machine. Proc Natl Acad Sci U S A. 2007 Jun 5;104(23):9553-4. Epub 2007 May 29.
The clockwork of metabolism. Ramsey KM, Marcheva B, Kohsaka A, Bass J. Annu Rev Nutr. 2007;27:219-40. Review.
View all publications by Joseph Bass listed in the National Library of Medicine (PubMed). (IBiS students in blue)