Jason H. Brickner
DNA and proteins are non-randomly localized within the nucleus of the cell. The Brickner lab studies how cells control the position of genes within the nucleus, and how gene positioning affects gene expression. When genes are activated or repressed, their position in the nucleus often changes. The lab has identified DNA "zip codes" in the promoters of genes that control their positioning, transcription and, through an epigenetic mechanism, chromatin structure.
Subnuclear positioning and interchromosomal clustering of the GAL1-10 locus are controlled by separable, interdependent mechanisms. Brickner DG, Sood V, Tutucci E, Coukos R, Viets K, Singer RH, and Brickner JH. Molecular Biology of the Cell. 2016 October 1;27(19):2980-2993.
Transcription factors dynamically control the spatial organization of the yeast genome. Randise-Hinchliff C and Brickner JH. Nucleus. 2016 July 21;7(4):369-374.
Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory. D'Urso A, Takahashi Y-H, Xiong B, Marone J, Coukos R, Randise-Hinchliff C, Wang J-P, Shilatifard A, and Brickner JH. eLife. 2016 June 23;5:e16691.
Strategies to regulate transcription factor–mediated gene positioning and interchromosomal clustering at the nuclear periphery. Randise-Hinchliff C, Coukos R, Sood V, Sumner MC, Zdraljevic S, Meldi Sholl L, Brickner DG, Ahmed S, Watchmaker L, and Brickner JH. Journal of Cell Biology. 2016 March 14;212(6):633-646.
INO1 transcriptional memory leads to DNA zip code-dependent interchromosomal clustering. Brickner DG, Coukos R, and Brickner JH. Microbial Cell. 2015 December;2(12):481-490.
Mechanisms of epigenetic memory. D'Urso A and Brickner JH. Trends in Genetics. 2014 June;30(6):230-236.
Nuclear pore interactions with the genome. Sood V and Brickner JH. Current Opinion in Genetics & Development. 2014 April;25:43-49.
Nuclear pore proteins regulate chromatin structure and transcriptional memory by a conserved mechanism. Light WH and Brickner JH. Nucleus. 2013 September/October;4(5):357-360.
A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory. Light WH, Freaney J, Sood V, Thompson A, D’Urso A, Horvath CM, and Brickner JH. PLoS Biology. 2013 March 26;11(3):e1001524.
Vps Factors Are Required for Efficient Transcription Elongation in Budding Yeast. Gaur NA, Hasek J, Brickner DG, Qiu H, Zhang F, Wong C-M, Malcova I, Vasicova P, Brickner JH, and Hinnebusch AG. Genetics. 2013 March 1;193(3):829-851.
Interchromosomal clustering of active genes at the nuclear pore complex. Brickner DG and Brickner JH. Nucleus. 2012 November/December;3(6):487-492.
A New Direction for Gene Looping. Randise-Hinchliff CE and Brickner JH. Developmental Cell. 2012 November 13;23(5):919-921.
Transcription Factor Binding to a DNA Zip Code Controls Interchromosomal Clustering at the Nuclear Periphery. Brickner DG, Ahmed S, Meldi L, Thompson A, Light W, Young M, Hickman TL, Chu F, Fabre E, and Brickner JH. Developmental Cell. 2012 June 12;22(6):1234-1246.
Compartmentalization of the nucleus. Meldi L and Brickner JH. Trends in Cell Biology. 2011 December;21(12):701-708.
Nuclear Architecture: The Cell Biology of a Laminopathy. Brickner JH. Current Biology. 2011 October 11;21(19):R807-R809.
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat. Leung A, Cajigas I, Jia P, Ezhkova E, Brickner JH, Zhao Z, Geng F, and Tansey WP. Molecular Biology of the Cell. 2011 August 1;22(15):2741-2753.
Gene positioning and expression. Egecioglu D and Brickner JH. Current Opinion in Cell Biology. 2011 June;23(3):338-345.
Gene positioning is regulated by phosphorylation of the nuclear pore complex by Cdk1. Brickner DG and Brickner JH. Cell Cycle. 2011 February 1;10(3):392-395.
View all publications by Jason H. Brickner listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.