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Jason Brickner

Jason H. Brickner

Associate Professor
Molecular Biosciences
PhD, Stanford University

Email: j-brickner@northwestern.edu
Phone: (847) 467-0210
Fax: (847) 467-1380
Room: Pancoe 3105


To Lab site

Research Interests

DNA and proteins are non-randomly localized within the nucleus of the cell. The Brickner lab studies how cells control the position of genes within the nucleus, and how gene positioning affects gene expression. When genes are activated or repressed, their position in the nucleus often changes. The lab has identified DNA "zip codes" in the promoters of genes that control their positioning, transcription and, through an epigenetic mechanism, chromatin structure.

Selected Publications

Mechanisms of epigenetic memory. D'Urso A and Brickner JH. Trends in Genetics. 2014 June;30(6):230-236.

Nuclear pore interactions with the genome. Sood V and Brickner JH. Current Opinion in Genetics & Development. 2014 April;25:43-49.

Nuclear pore proteins regulate chromatin structure and transcriptional memory by a conserved mechanism. Light WH and Brickner JH. Nucleus. 2013 September/October;4(5):357-360.

A Conserved Role for Human Nup98 in Altering Chromatin Structure and Promoting Epigenetic Transcriptional Memory. Light WH, Freaney J, Sood V, Thompson A, D’Urso A, Horvath CM, and Brickner JH. PLoS Biology. 2013 March 26;11(3):e1001524.

Vps Factors Are Required for Efficient Transcription Elongation in Budding Yeast. Gaur NA, Hasek J, Brickner DG, Qiu H, Zhang F, Wong C-M, Malcova I, Vasicova P, Brickner JH, and Hinnebusch AG. Genetics. 2013 March 1;193(3):829-851.

Interchromosomal clustering of active genes at the nuclear pore complex. Brickner DG and Brickner JH. Nucleus. 2012 November/December;3(6):487-492.

A New Direction for Gene Looping. Randise-Hinchliff CE and Brickner JH. Developmental Cell. 2012 November 13;23(5):919-921.

Transcription Factor Binding to a DNA Zip Code Controls Interchromosomal Clustering at the Nuclear Periphery. Brickner DG, Ahmed S, Meldi L, Thompson A, Light W, Young M, Hickman TL, Chu F, Fabre E, and Brickner JH. Developmental Cell. 2012 June 12;22(6):1234-1246.

Compartmentalization of the nucleus. Meldi L and Brickner JH. Trends in Cell Biology. 2011 December;21(12):701-708.

Nuclear Architecture: The Cell Biology of a Laminopathy. Brickner JH. Current Biology. 2011 October 11;21(19):R807-R809.

Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat. Leung A, Cajigas I, Jia P, Ezhkova E, Brickner JH, Zhao Z, Geng F, and Tansey WP. Molecular Biology of the Cell. 2011 August 1;22(15):2741-2753.

Gene positioning and expression. Egecioglu D and Brickner JH. Current Opinion in Cell Biology. 2011 June;23(3):338-345.

Gene positioning is regulated by phosphorylation of the nuclear pore complex by Cdk1. Brickner DG and Brickner JH. Cell Cycle. 2011 February 1;10(3):392-395.

Interaction of a DNA Zip Code with the Nuclear Pore Complex Promotes H2A.Z Incorporation and INO1 Transcriptional Memory. Light WH, Brickner DG, Brand VR, and Brickner JH. Molecular Cell. 2010 October 8;40(1):112-125.

Cdk Phosphorylation of a Nucleoporin Controls Localization of Active Genes through the Cell Cycle. Brickner DG and Brickner JH. Molecular Biology of the Cell. 2010 October 1;21(19):3421-3432.

A role for DNA sequence in controlling the spatial organization of the genome. Ahmed S and Brickner JH. Nucleus. 2010 September/October;1(5):402-406.

DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery. Ahmed S, Brickner DG, Light WH, Cajigas I, McDonough M, Froyshteter AB, Volpe T, and Brickner JH. Nature Cell Biology. 2010 February;12(2):111-118.

Transcriptional Memory: Staying in the Loop. Brickner JH. Current Biology. 2010 January 12;20(1):R20-R21.

Quantitative Localization of Chromosomal Loci by Immunofluorescence. Brickner DG, Light W, and Brickner JH. Methods in Enzymology. 2010;470:569-580.

Cohesinopathy mutations disrupt the subnuclear organization of chromatin. Gard S, Light W, Xiong B, Bose T, McNairn AJ, Harris B, Fleharty B, Seidel C, Brickner JH, and Gerton JL. Journal of Cell Biology. 2009 November 16;187(4):455-462.

Transcriptional memory at the nuclear periphery. Brickner JH. Current Opinion in Cell Biology. 2009 February;21(1):127-133.

Regulation and epigenetic control of transcription at the nuclear periphery. Ahmed S and Brickner JH. Trends in Genetics. 2007 August; 23(8):396-402.

H2A.Z-Mediated Localization of Genes at the Nuclear Periphery Confers Epigenetic Memory of Previous Transcriptional State. Brickner DG, Cajigas I, Fondufe-Mittendorf Y, Ahmed S, Lee P-C, Widom J, and Brickner JH. PLoS Biology. 2007 April;5(4):e81.

Gene Recruitment of the Activated INO1 Locus to the Nuclear Membrane. Brickner JH and Walter P. PLoS Biology. 2004 November;2(11):e342.

View all publications by Jason H. Brickner listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.