Owen L. Coon Professor
Quantitative and Systems Biology
Our group studies how complex cell and tissue behaviors are elicited within the context of the organism. We work as experimentalists, teaming up with theorists in applied mathematics, physics, and engineering, to apply systematic and quantitative approaches to biological problems. Gene regulation is of particular interest, and we have a long-standing interest in why non-coding RNAs regulate gene expression.
The irreversible transition of cells to a differentiated state is a continual process throughout life. Although the signaling and regulatory molecules required for many differentiation processes are known, they alone do not explain this emergent property of animal cells. We apply quantitative methods to the problem, and consider all manner of cues received by cells, including those of a biochemical or mechanical nature.The irreversible transition of cells to a differentiated state is a continual process throughout life. Although the signaling and regulatory molecules required for many differentiation processes are known, they alone do not explain this emergent property of animal cells. We apply quantitative methods to the problem, and consider all manner of cues received by cells, including those of a biochemical or mechanical nature.
Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteins. Andress A, Bei Y, Fonslow BR, Giri R, Wu Y, Yates JR, and Carthew RW. Journal of Cell Biology. 2016 April 25;213(2):201-211.
MicroRNA function in Drosophila melanogaster. Carthew RW, Agbu P, and Giri R. Seminars in Cell & Developmental Biology. 2016 March 18:ePub before print.
Differential Masking of Natural Genetic Variation by miR-9a in Drosophila. Cassidy JJ, Straughan AJ, and Carthew RW. Genetics. 2016 February;202(2):675-687.
Dynamics and heterogeneity of a fate determinant during transition towards cell differentiation. Peláez N, Gavalda-Miralles A, Wang B, Tejedor Navarro H, Gudjonson H, Rebay I, Dinner AR, Katsaggelos AK, Amaral LAN, and Carthew RW. eLife. 2015 November 19;4:e08924.
A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling. Boisclair Lachance J-F, Peláez N, Cassidy JJ, Webber JL, Rebay I, and Carthew RW. Developmental Biology. 2014 January 15;385(2):263-278.
miR-9a Minimizes the Phenotypic Impact of Genomic Diversity by Buffering a Transcription Factor. Cassidy JJ, Jha AR, Posadas DM, Giri R, Venken KJT, Ji J, Jiang H, Bellen HJ, White KP, and Carthew RW. Cell. 2013 December 19;155(7):1556-1567.
Functionally Diverse MicroRNA Effector Complexes Are Regulated by Extracellular Signaling. Wu P-H, Isaji M, and Carthew RW. Molecular Cell. 2013 October 10;52(1):113-123.
Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection. Marques JT, Wang J-P, Wang X, de Oliveira KPV, Gao C, Aguiar ERGR, Jafari N, and Carthew RW. PLoS Pathogens. 2013 August 29;9(8):e1003579.
The Relationship Between Long-Range Chromatin Occupancy and Polymerization of the Drosophila ETS Family Transcriptional Repressor Yan. Webber JL, Zhang J, Cote L, Vivekanand P, Ni X, Zhou J, Nègre N, Carthew RW, White KP, and Rebay I. Genetics. 2013 February 1;193(2):633-649.
Tobacco calmodulin-like protein provides secondary defense by binding to and directing degradation of virus RNA silencing suppressors. Nakahara KS, Masuta C, Yamada S, Shimura H, Kashihara Y, Wada TS, Meguro A, Goto K, Tadamura K, Sueda K, Sekiguchi T, Shao J, Itchoda N, Matsumura T, Igarashi M, Ito K, Carthew RW, and Uyeda I. PNAS. 2012 June 19;109(25):10113-10118.
A Systematic Genetic Screen to Dissect the MicroRNA Pathway in Drosophila. Pressman S, Reinke CA, Wang X, and Carthew RW. G3. 2012 April 1;2(4):437-448.
Biological Robustness and the Role of MicroRNAs: A Network Perspective. Peláez N and Carthew RW. Current Topics in Developmental Biology. 2012;99:237-255.
Cadherin-Dependent Cell Morphology in an Epithelium: Constructing a Quantitative Dynamical Model. Gemp IM, Carthew RW, and Hilgenfeldt S. PLoS Computational Biology. 2011 July 21;7(7):e1002115.
View all publications by Richard Carthew listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.