Faculty

Richard F. Gaber, PhD

Professor
Molecular Biosciences
PhD. University of Wisconsin at Madison

Email: r-gaber@northwestern.edu
Phone: (847) 491-5452
Fax: (847) 467-1422
Room: Cook Rm 3135

Research Interests

The main area of interest for my laboratory involves signaling through the molecular chaperone known as the Hsp90. We have recently discovered that a key role of the Hsp90 complex of proteins is to negatively regulate the cell's ability to respond to heat shock. Hsp90 and the cyclophilin, Cpr7, keep this signal transduction pathway repressed under non-stress conditions. In related studies, we discovered a new component of the Hsp90 complex, Cns1, that is essential for life in S. cerevisiae. Cns1, like certain other Hsp90-associated protiens contains multiple tetra-tricopeptide repeat (TPR) motifs and it is through these domains that the interactions between Hsp90 and Cns1 appear to depend. Our goal is to discover specific essential in vivo role(s) played by the Hsp90 complex with particular emphasis on the part played by Cns1.

Selected Publications

Ion selectivity of the Kat1 K+ channel pore. Nakamura RL, Gaber RF. Mol Membr Biol. 2009 Aug;26(5):293-308. Epub 2009 Sep 8. 

Hyper- and hyporesponsive mutant forms of the Saccharomyces cerevisiae Ssy1 amino acid sensor. Poulsen P, Gaber RF, Kielland-Brandt MC. Mol Membr Biol. 2008 Feb;25(2):164-76. 

Wu B, Ottow K, Poulsen P, Gaber RF, Albers E, Kielland-Brandt MC. Competitive intra- and extracellular nutrient sensing by the transporter homologue Ssy1p. J Cell Biol. 2006 May 8;173(3):327-31. Epub 2006 May 1.

P. Poulsen, B. Wu, R. F. Gaber & M. C. Kielland-Brandt (2005). "Constitutive signal transduction by mutant Ssy5p and Ptr3p components of the SPS amino acid sensor system in Saccharomyces cerevisiae." Eukaryot Cell 4, 1116-24.

View all publications by publications by Richard F. Gaber listed in the National Library of Medicine