Faculty
Erwin Goldberg, PhD
Professor
Biochemistry, Molecular Biology, and Cell Biology
PhD, University of Iowa
Email: erv@northwestern.edu
Phone: (847) 491-5416
Fax: (847) 467-1380
Room: Hogan Rm 4-100
Research Interests
Biochemistry and molecular biology of mammalian spermatogenesis
Mammalian spermatogenesis is a complex process of cellular differentiation involving unique cytological and molecular processes that culminate in formation of spermatozoa. At present, particular emphasis is given to enzymes and proteins that appear during mammalian spermatogenesis and that are unique to the spermatozoon. This is best seen with the unique form of lactate dehydrogenase (LDH-C4) that is synthesized in the primary spermatocyte during mid- pachytene of the first meiotic division. Studies are in progress on the nature of mechanisms regulating this remarkable time and cell-specific process, as well as with the molecular aspects of LDH-C4 itself. We have cloned and sequenced the Ldh-c gene and are characterizing the regulatory regions involved in specific gene activation. Also, the cell specificity of LDH-C4 is being examined with reference to problems in contraception technology and fertility control. These data are directly relevant to understanding control of gene expression during development and to gene mis-expression associated with cancer and infertility.
Selected Publications
LDHC THE ULTIMATE TESTIS SPECIFIC GENE. Goldberg E, Eddy EM, Duan C, Odet F. J Androl. 2009 Oct 29. [Epub ahead of print]
Computational analyses of mammalian lactate dehydrogenases: human, mouse, opossum and platypus LDHs. Holmes RS, Goldberg E. Comput Biol Chem. 2009 Oct;33(5):379-85. Epub 2009 Jul 19.
Homo sapiens lactate dehydrogenase c (Ldhc) gene expression in cancer cells is regulated by transcription factor Sp1, CREB, and CpG island methylation. Tang H, Goldberg E. J Androl. 2009 Mar-Apr;30(2):157-67. Epub 2008 Oct 16.
Testis specific lactate dehydrogenase as target for immunoliposomes. Dutta RC, Goldberg E. Am J Reprod Immunol. 2008 Jul;60(1):26-32.
Expression of the gene for mouse lactate dehydrogenase C (Ldhc) is required for male fertility. Odet F, Duan C, Willis WD, Goulding EH, Kung A, Eddy EM, Goldberg E Biol Reprod. 2008 Jul;79(1):26-34. Epub 2008 Mar 26..
Regulation of murine lactate dehydrogenase C (Ldhc) gene expression. Tang H, Kung A, Goldberg E. Biol Reprod. 2008 Mar;78(3):455-61. Epub 2007 Dec 5.
Coonrod, S., Vitale, A., Duan, C., Bristol-Gould, S., Herr, J. and Goldberg, E. (2006) Testis-specific lactate dehydrogenase (LDH-C4; Ldh3) in Murine Oocytes and Preimplantation Embryos. J. Androl. 27: 502-509.
Medrano, A., Fernandez-Novell, J.M., Ramio, L., Alvarez, J., Goldberg, E., Montserrat Rivera, M., Guinovart, J.J., Rigau, T. and Rodriguez-Gil, J.E. (2006) Utilization of citrate and lactate through a lactate dehydrogenase and ATP-regulated pathway in boar spermatozoa. Mol. Reprod. Dev. 73 :369-378.
Duan, C. and Goldberg, E. (2005) Catalytic and non-catalytic functions of testis specific lactate dehydrogenase. In: Proceedings of the 13th International Congress on Genes, Gene Families and Isobymes, Shanghai, China, September 17-21, 2005.
View all publications by Erwin Goldberg listed in the National Library of Medicine (PubMed).