Robert A. Linsenmeier
We are interested in the microenvironment in which the neurons of the retina work. Studying the distribution and regulation of ions, substrates and metabolites allows us to understand aspects of cell biology, physiology and energy metabolism in the intact retina. Also, many blinding diseases are caused by problems with the vasculature and its ability to supply nutrients to the tissue. Our work provides insight into these diseases.
Our recent work has been on the oxygenation of the cat retina, a good model for the human retina in many respects. We use oxygen-sensitive microelectrodes that measure oxygen levels with excellent spatial resolution. Simultaneously we measure local neural activity to provide an index of retinal function. The oxygen distribution in the retina of higher mammals is particularly interesting; oxygen is a critical nutrient, and it is supplied to the retina by two independent circulations, the retinal and choroidal, which have very different properties. The focus of our current work is to understand the relationships between oxidative and glycolytic metabolism in the retina, and to work on animal models for diseases such as retinal vascular occlusion, diabetic retinopathy, and photoreceptor degenerations.
Association of Diabetic Macular Nonperfusion with Outer Retinal Disruption on Optical Coherence Tomography. Scarinci F, Jampol LM, Linsenmeier RA, and Fawzi AA. JAMA Ophthalmology. 2015 September;133(9):1036-1044.
Increased Intraretinal PO2 in Short-Term Diabetic Rats. Lau JCM and Linsenmeier RA. Diabetes. 2014 December;63(12):4338-4342.
A combined method to quantify the retinal metabolic rate of oxygen using photoacoustic ophthalmoscopy and optical coherence tomography. Song W, Wei Q, Liu W, Liu T, Yi J, Sheibani N, Fawzi AA, Linsenmeier RA, Jiao S, and Zhang HF. Scientific Reports. 2014 October 6;4:6525.
Diabetes changes expression of genes related to glutamate neurotransmission and transport in the Long-Evans rat retina. Lau JCM, Kroes RA, Moskal JR, and Linsenmeier RA. Molecular Vision. 2013 July 19;19:1538-1553.
Oxygen consumption and distribution in the Long-Evans rat retina. Lau JCM and Linsenmeier RA. Experimental Eye Research. 2012 September;102:50-58.
Effect of isoflurane on brain tissue oxygen tension and cerebral autoregulation in rabbits. Aksenov D, Eassa JE, Lakhoo J, Wyrwicz A, and Linsenmeier RA. Neuroscience Letters. 2012 August 30;524(2):116-118.
Decreased Circulation in the Feline Choriocapillaris Underlying Retinal Photocoagulation Lesions. Lee CJ, Smith JH, Kang-Mieler JJ, Budzynski E, and Linsenmeier RA. Investigative Ophthalmology & Visual Science. 2011 May 20;52(6):3398-3403.
Metabolic Responses to Light in Monkey Photoreceptors. Wang S, Birol G, Budzynski E, Flynn R, and Linsenmeier RA. Current Eye Research. 2010 June;35(6):510-518.
Gene expression patterns in hypoxic and post-hypoxic adult rat retina with special reference to the NMDA receptor and its interactome. Crosson LA, Kroes RA, Moskal JR, and Linsenmeier RA. Molecular Vision. 2009;15:296-311.
Effects of Photocoagulation on Intraretinal PO2 in Cat. Budzynski E, Smith JH, Bryar P, Birol G, and Linsenmeier RA. Investigative Ophthalmology & Visual Science. 2008 January;49(1):380-389.
View all publications by Robert A. Linsenmeier listed in the National Library of Medicine (PubMed).