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Chad A. Mirkin

Chad A. Mirkin

George B. Rathmann Professor
Chemistry, Chemical & Biological Engineering, Biomedical Engineering, Materials Science & Engineering, Medicine
PhD, Pennsylvania State University

Email: chadnano@northwestern.edu
Phone: (847) 467-7302
Fax: (847) 467-5123
Room: Ryan 3012


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Research Interests

Our research focuses on developing strategic and surface nano-optical methods for controlling the architecture of molecules and materials on a 1-100 nm scale. Our researchers, with backgrounds ranging from medicine, biology, chemistry, physics and material science, are working together in solving fundamental and applied problems of modern nanoscience. Research in the Mirkin laboratories is divided into five areas: Anisotropic Nanostructures, On-Wire Lithography (OWL), Dip-Pen Nanolithography, Organometallic Chemistry, and Spherical Nucleic Acids and Bioprogrammable Materials.

Selected Publications

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma. Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI, Daniel WL, Scott AW, Rotz MW, Meade TJ, Giljohann DA, Mirkin CA, and Stegh AH. Science Translational Medicine. 2013 October 30;5(209):209ra152.

Desktop nanofabrication with massively multiplexed beam pen lithography. Liao X, Brown KA, Schmucker AL, Liu G, He S, Shim W, and Mirkin CA. Nature Communications. 2013 July 19;4:2103.

Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates. Choi CHJ, Hao L, Narayan SP, Auyeung E, and Mirkin CA. PNAS. 2013 May 7;110(19):7625-7630.

Antibody-Linked Spherical Nucleic Acids for Cellular Targeting. Zhang K, Hao L, Hurst SJ, and Mirkin CA. Journal of the American Chemical Society. 2012 October 10;134(40):16488-16491.

Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation. Zheng D, Giljohann DA, Chen DL, Massich MD, Wang X-Q, Iordanov H, Mirkin CA, and Paller AS. PNAS. 2012 July 24;109(30):11975-11980.

Hollow Spherical Nucleic Acids for Intracellular Gene Regulation Based upon Biocompatible Silica Shells. Young KL, Scott AW, Hao L, Mirkin SE, Liu G, and Mirkin CA. Nano Letters. 2012 July 11;12(7):3867-3871.

Scanometric MicroRNA Array Profiling of Prostate Cancer Markers Using Spherical Nucleic Acid–Gold Nanoparticle Conjugates. Alhasan AH, Kim DY, Daniel WL, Watson E, Meeks JJ, Thaxton CS, and Mirkin CA. Analytical Chemistry. 2012 May 1;84(9):4153-4160.

Scanning probe-enabled nanocombinatorics define the relationship between fibronectin feature size and stem cell fate. Giam LR, Massich MD, Hao L, Wong LS, Mader CC, and Mirkin CA. PNAS. 2012 March 20;109(12):4377-4382.

Multiplexed Nanoflares: mRNA Detection in Live Cells. Prigodich AE, Randeria PS, Briley WE, Kim NJ, Daniel WL, Giljohann DA, and Mirkin CA. Analytical Chemistry. 2012 February 21;84(4):2062-2066.

Tailoring of Biomimetic High-Density Lipoprotein Nanostructures Changes Cholesterol Binding and Efflux. Luthi AJ, Zhang H, Kim D, Giljohann DA, Mirkin CA, and Thaxton CS. ACS Nano. 2012 January 24;6(1):276-285.

Nanoparticle Shape Anisotropy Dictates the Collective Behavior of Surface-Bound Ligands. Jones MR, Macfarlane RJ, Prigodich AE, Patel PC, and Mirkin CA. Journal of the American Chemical Society. 2011 November 23;133(46):18865-18869.

Nucleic Acid–Gold Nanoparticle Conjugates as Mimics of microRNA. Hao L, Patel PC, Alhasan AH, Giljohann DA, and Mirkin CA. Small. 2011 November 18;7(22):3158-3162.

Duplex End Breathing Determines Serum Stability and Intracellular Potency of siRNA–Au NPs. Patel PC, Hao L, Au Yeung WS, and Mirkin CA. Molecular Pharmaceutics. 2011 August 1;8(4):1285-1291.

View all publications by Chad A. Mirkin listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.