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Chad A. Mirkin

Chad A. Mirkin

George B. Rathmann Professor
Chemistry, Chemical & Biological Engineering, Biomedical Engineering, Materials Science & Engineering, Medicine
PhD, Pennsylvania State University

Email: chadnano@northwestern.edu
Phone: (847) 467-7302
Fax: (847) 467-5123
Room: Ryan 3012


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Research Interests

Our research focuses on developing strategic and surface nano-optical methods for controlling the architecture of molecules and materials on a 1-100 nm scale. Our researchers, with backgrounds ranging from medicine, biology, chemistry, physics and material science, are working together in solving fundamental and applied problems of modern nanoscience. Research in the Mirkin laboratories is divided into five areas: Anisotropic Nanostructures, On-Wire Lithography (OWL), Dip-Pen Nanolithography, Organometallic Chemistry, and Spherical Nucleic Acids and Bioprogrammable Materials.

Selected Publications

miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma. Kouri FM, Hurley LA, Daniel WL, Day ES, Hua Y, Hao L, Peng C-Y, Merkel TJ, Queisser MA, Ritner C, Zhang H, James CD, Sznajder JI, Chin L, Giljohann DA, Kessler JA, Peter ME, Mirkin CA, and Stegh AH. Genes & Development. 2015 April 1;29(7):732-745.

Immunomodulatory spherical nucleic acids. Radovic-Moreno AF, Chernyak N, Mader CC, Nallagatla S, Kang RS, Hao L, Walker DA, Halo TL, Merkel TJ, Rische CH, Anantatmula S, Burkhart M, Mirkin CA, and Gryaznov SM. PNAS. 2015 March 31;112(13):3892-3897.

Nanoflares as Probes for Cancer Diagnostics. Randeria PS, Briley WE, Chinen AB, Guan CM, Petrosko SH, and Mirkin CA. Cancer Treatment and Research. 2015;166:1-22.

Spherical Nucleic Acids as a Divergent Platform for Synthesizing RNA-Nanoparticle Conjugates through Enzymatic Ligation. Rouge JL, Hao L, Wu XA, Briley WE, and Mirkin CA. ACS Nano. 2014 September 23;8(9):8837-8843.

A Multi-State, Allosterically-Regulated Molecular Receptor With Switchable Selectivity. Mendez-Arroyo J, Barroso-Flores J, Lifschitz AM, Sarjeant AA, Stern CL, and Mirkin CA. Journal of the American Chemical Society. 2014 July 23;136(29):10340-10348.

Intracellular Fate of Spherical Nucleic Acid Nanoparticle Conjugates. Wu XA, Choi CHJ, Zhang C, Hao L, and Mirkin CA. Journal of the American Chemical Society. 2014 May 28;136(21):7726-7733.

Nucleic Acid-Metal Organic Framework (MOF) Nanoparticle Conjugates. Morris W, Briley WE, Auyeung E, Cabezas MD, and Mirkin CA. Journal of the American Chemical Society. 2014 May 21;136(20):7261-7264.

Exosome Encased Spherical Nucleic Acid Gold Nanoparticle Conjugates as Potent MicroRNA Regulation Agents. Alhasan AH, Patel PC, Choi CHJ, and Mirkin CA. Small. 2014 January 15;10(1):186-192.

DNA-mediated nanoparticle crystallization into Wulff polyhedra. Auyeung E, Li T, Senesi AJ, Schmucker AL, Pals BC, Olvera de la Cruz M, and Mirkin CA. Nature. 2014 January 2;505(7481):73-77.

Combinatorial Screening of Mesenchymal Stem Cell Adhesion and Differentiation Using Polymer Pen Lithography. Cabezas MD, Eichelsdoerfer DJ, Brown KA, Mrksich M, and Mirkin CA. Methods in Cell Biology. 2014;119:261-276.

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma. Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI, Daniel WL, Scott AW, Rotz MW, Meade TJ, Giljohann DA, Mirkin CA, and Stegh AH. Science Translational Medicine. 2013 October 30;5(209):209ra152.

Topotactic Interconversion of Nanoparticle Superlattices. Macfarlane RJ, Jones MR, Lee B, Auyeung E, and Mirkin CA. Science. 2013 September 13;341(6151):1222-1225.

A general approach to DNA-programmable atom equivalents. Zhang C, Macfarlane RJ, Young KL, Choi CHJ, Hao L, Auyeung E, Liu G, Zhou X, and Mirkin CA. Nature Materials. 2013 August;12(8):741-746.

Mechanism for the endocytosis of spherical nucleic acid nanoparticle conjugates. Choi CHJ, Hao L, Narayan SP, Auyeung E, and Mirkin CA. PNAS. 2013 May 7;110(19):7625-7630.

View all publications by Chad A. Mirkin listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.