Faculty
Karl A. Scheidt
Associate Professor
Chemistry
PhD, Indiana University
Email: scheidt@northwestern.edu
Phone: (847) 491-6659
Fax: (847) 491-7713
Room: Silverman 3609
Research Interests
Our research focuses on these complementary areas: Drug discovery, bioorganic chemistry, and small molecule-driven chemical biology. We are particularly interested in designing novel methods and strategies for the construction of complex natural products with important biological attributes. Our methodology programs encompass assembling molecules and introducing stereogenic centers using new catalytic reactions.
Selected Publications
A Continuum of Progress: Applications of N-Hetereocyclic Carbene Catalysis in Total Synthesis. Izquierdo J, Hutson GE, Cohen DT, and Scheidt KA. Angewandte Chemie. 2012 November 19;51(47):11686-11698.
Assembly of Four Diverse Heterocyclic Libraries Enabled by Prins Cyclization, Au-Catalyzed Enyne Cycloisomerization, and Automated Amide Synthesis. Cui J, Chai DI, Miller C, Hao J, Thomas C, Wang JQ, Scheidt KA, and Kozmin SA. Journal of Organic Chemistry. 2012 September 7;77(17):7435-7470.
N-Heterocyclic Carbene-Like Catalysis by a Metal-Organic Framework Material. Lalonde MB, Farha OK, Scheidt KA, and Hupp JT. ACS Catalysis. 2012 August 3;2(8):1550-1554.
Catalytic Dynamic Kinetic Resolutions with N-Heterocyclic Carbenes: Asymmetric Synthesis of Highly Substituted β-Lactones. Cohen DT, Eichman CC, Phillips EM, Zarefsky ER, and Scheidt KA. Angewandte Chemie. 2012 July 16;51(29):7309-7313.
An N-Heterocyclic Carbene/Lewis Acid Strategy for the Stereoselective Synthesis of Spirooxindole Lactones. Dugal-Tessier J, O'Bryan EA, Schroeder TBH, Cohen DT, and Scheidt KA. Angewandte Chemie. 2012 May 14;51(20):4963-4967.
Urea Metal-Organic Frameworks as Effective and Size-Selective Hydrogen-Bond Catalysts. Roberts JM, Fini BM, Sarjeant AA, Farha OK, Hupp JT, and Scheidt KA. Journal of the American Chemical Society. 2012 February 22;134(7):3334-3337.
Single-Molecule Tip-Enhanced Raman Spectroscopy. Sonntag MD, Klingsporn JM, Garibay LK, Roberts JM, Dieringer JA, Seideman T, Scheidt KA, Jensen L, Schatz GC, and Van Duyne RP. Journal of Physical Chemistry C. 2012 January 12;116(1):478-483.
Asymmetric Methods for the Synthesis of Flavanones, Chromanones, and Azaflavanones. Nibbs AE and Scheidt KA. European Journal of Organic Chemistry. 2012 January;2012(3):449-462.
Lewis base-promoted carbon–carbon sp3–sp3 coupling reactions of α-silyl silylethers. Brekan JA, Chernyak D, White KL, and Scheidt KA. Chemical Science. 2012;3(4):1205-1210.
Cooperative Lewis acid/N-heterocyclic carbene catalysis. Cohen DT and Scheidt KA. Chemical Science. 2012;3(1):53-57.
View all publications by Karl A. Scheidt listed in the National Library of Medicine (PubMed).