Chad A. Mirkin Professor of Chemistry, Chemical & Biological Engineering, Biomedical Engineering, Materials Science & Engineering, Medicine

Research Interests

Our research focuses on developing strategic and surface nano-optical methods for controlling the architecture of molecules and materials on a 1-100 nm scale. Our researchers, with backgrounds ranging from medicine, biology, chemistry, physics and material science, are working together in solving fundamental and applied problems of modern nanoscience. Research in the Mirkin laboratories is divided into five areas: Anisotropic Nanostructures, On-Wire Lithography (OWL), Dip-Pen Nanolithography, Organometallic Chemistry, and Spherical Nucleic Acids and Bioprogrammable Materials.

Selected Publications

Dual bioluminescence and near-infrared fluorescence monitoring to evaluate spherical nucleic acid nanoconjugate activity in vivoSita TL, Kouri FM, Hurley LA, Merkel TJ, Chalastanis A, May JL, Ghelfi ST, Cole LE, Cayton TC, Barnaby SN, Sprangers AJ, Savalia N, James CD, Lee A, Mirkin CA, and Stegh AH. PNAS. 2017 April 18;114(16):4129-4134.

Relationships between Poly(ethylene glycol) Modifications on RNA–Spherical Nucleic Acid Conjugates and Cellular Uptake and Circulation Time. Chinen AB, Ferrer JR, Merkel TJ, and Mirkin CA. Bioconjugate Chemistry. 2016 November 16;27(11):2715-2721.

Circulating microRNA signature for the diagnosis of very high-risk prostate cancerAlhasan AH, Scott AW, Wu JJ, Feng G, Meeks JJ, Thaxton CS, and Mirkin CA. PNAS. 2016 September 20;113(38):10655-10660.

Spherical nucleic acid targeting microRNA-99b enhances intestinal MFG-E8 gene expression and restores enterocyte migration in lipopolysaccharide-induced septic mice. Wang X, Hao L, Bu H-F, Scott AW, Tian K, Liu F, De Plaen IG, Liu Y, Mirkin CA, and Tan X-D. Scientific Reports. 2016 August 19;6:31687.

Biodegradable DNA-Brush Block Copolymer Spherical Nucleic Acids Enable Transfection Agent-Free Intracellular Gene Regulation. Zhang C, Hao L, Calabrese CM, Zhou Y, Choi CHJ, Xing H, and Mirkin CA. Small. 2015 October 28;11(40):5360-5368.

Nanoparticle Probes for the Detection of Cancer Biomarkers, Cells, and Tissues by Fluorescence. Chinen AB, Guan CM, Ferrer JR, Barnaby SN, Merkel TJ, and Mirkin CA. Chemical Reviews. 2015 October 14;115(19):10530-10574.

The Sequence-Specific Cellular Uptake of Spherical Nucleic Acid Nanoparticle Conjugates. Narayan SP, Choi CHJ, Hao L, Calabrese CM, Auyeung E, Zhang C, Goor OJGM, and Mirkin CA. Small. 2015 September 2;11(33):4173-4182.

Ribozyme–Spherical Nucleic Acids. Rouge JL, Sita TL, Hao L, Kouri FM, Briley WE, Stegh AH, and Mirkin CA. Journal of the American Chemical Society. 2015 August 26;137(33):10528-10531.

Quantification and real-time tracking of RNA in live cells using Sticky-flaresBriley WE, Bondy MH, Randeria PS, Dupper TJ, and Mirkin CA. PNAS. 2015 August 4;112(31):9591-9595.

miR-182 integrates apoptosis, growth, and differentiation programs in glioblastoma. Kouri FM, Hurley LA, Daniel WL, Day ES, Hua Y, Hao L, Peng C-Y, Merkel TJ, Queisser MA, Ritner C, Zhang H, James CD, Sznajder JI, Chin L, Giljohann DA, Kessler JA, Peter ME, Mirkin CA, and Stegh AH. Genes & Development. 2015 April 1;29(7):732-745.

Immunomodulatory spherical nucleic acids. Radovic-Moreno AF, Chernyak N, Mader CC, Nallagatla S, Kang RS, Hao L, Walker DA, Halo TL, Merkel TJ, Rische CH, Anantatmula S, Burkhart M, Mirkin CA, and Gryaznov SM. PNAS. 2015 March 31;112(13):3892-3897.

Nanoflares as Probes for Cancer Diagnostics. Randeria PS, Briley WE, Chinen AB, Guan CM, Petrosko SH, and Mirkin CA. Cancer Treatment and Research. 2015;166:1-22.

Therapeutic Applications of Spherical Nucleic Acids. Barnaby SN, Sita TL, Petrosko SH, Stegh AH, and Mirkin CA. Cancer Treatment and Research. 2015;166:23-50.

NanoFlares for the detection, isolation, and culture of live tumor cells from human blood. Halo TL, McMahon KM, Angeloni NL, Xu Y, Wang W, Chinen AB, Malin D, Strekalova E, Cryns VL, Cheng C, Mirkin CA, and Thaxton CS. PNAS. 2014 December 2;111(48):17104-17109.

Spherical Nucleic Acids as a Divergent Platform for Synthesizing RNA-Nanoparticle Conjugates through Enzymatic Ligation. Rouge JL, Hao L, Wu XA, Briley WE, and Mirkin CA. ACS Nano. 2014 September 23;8(9):8837-8843.

Intracellular Fate of Spherical Nucleic Acid Nanoparticle ConjugatesWu XA, Choi CHJ, Zhang C, Hao L, and Mirkin CA. Journal of the American Chemical Society. 2014 May 28;136(21):7726-7733.

Exosome Encased Spherical Nucleic Acid Gold Nanoparticle Conjugates as Potent MicroRNA Regulation AgentsAlhasan AH, Patel PC, Choi CHJ, and Mirkin CA. Small. 2014 January 15;10(1):186-192.

View all publications by Chad A. Mirkin listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.