Chad A. Mirkin Professor of Chemistry, Chemical & Biological Engineering, Biomedical Engineering, Materials Science & Engineering, Medicine

Research Interests

Research in the Mirkin Group focuses on developing methods for controlling the architecture of molecules and materials on the 1 – 100 nm length scale, understanding their fundamental properties, and utilizing such structures to develop novel tools that can be applied in the areas of chemical and biological sensing, gene regulation, immunomodulation, lithography, catalysis, optics, and energy generation, storage, and conversion. The Mirkin Research Group has pioneered the use of nanoparticle-biomolecule conjugates, most notably spherical nucleic acids (SNAs), as synthons in materials science, probes in extra- and intracellular biodiagnostic schemes, and agents for therapeutic tools involving gene regulation and immunomodulation.

Selected Publications

Immunomodulatory spherical nucleic acids. Radovic-Moreno AF, Chernyak N, Mader CC, Nallagatla S, Kang RS, Hao L, Walker DA, Halo TL, Merkel TJ, Rische CH, Anantatmula S, Burkhart M, Mirkin CA, and Gryaznov SM. PNAS. 2015 March 31;112(13):3892-3897.

Spherical Nucleic Acid Nanoparticle Conjugates as an RNAi-Based Therapy for Glioblastoma. Jensen SA, Day ES, Ko CH, Hurley LA, Luciano JP, Kouri FM, Merkel TJ, Luthi AJ, Patel PC, Cutler JI, Daniel WL, Scott AW, Rotz MW, Meade TJ, Giljohann DA, Mirkin CA, and Stegh AH. Science Translational Medicine. 2013 October 30;5(209):209ra152.

Topical delivery of siRNA-based spherical nucleic acid nanoparticle conjugates for gene regulation. Zheng D, Giljohann DA, Chen DL, Massich MD, Wang X-Q, Iordanov H, Mirkin CA, and Paller AS. PNAS. 2012 July 24;109(30):11975-11980.

Oligonucleotide-Modified Gold Nanoparticles for Intracellular Gene Regulation. Rosi NL, Giljohann DA, Thaxton CS, Lytton-Jean AKR, Han MS, and Mirkin CA. Science. 2006 May 19;312(5776):1027-1030.

A DNA-based method for rationally assembling nanoparticles into macroscopic materials. Mirkin CA, Letsinger RL, Mucic RC, and Storhoff JJ. Nature. 1996 August 15;382(6592):607-609.

View all publications by Chad A. Mirkin listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.