Daniel A. Dombeck Associate Professor of Neurobiology

Research Interests

Optical Dissection of the Neuronal Circuits Underlying Mammalian Navigation

The neuronal activity underlying mammalian spatial navigation represents one of the most striking examples of behavioral correlation in the brain. We are interested in the cellular and circuit mechanisms responsible for the neuronal activity that allows mammals to navigate and find their way to specific destinations. To accomplish this, we develop and apply novel optical and genetic techniques to perform cellular and subcellular resolution imaging and manipulation of neuronal population activity in mice navigating in virtual reality environments. By understanding the navigation circuitry, we hope to extract general principles about neuronal population dynamics in behaving mammals.

Selected Publications

Calcium transient prevalence across the dendritic arbour predicts place field properties. Sheffield MEJ and Dombeck DA. Nature. 2015 January 8;517(7533):200-204.

The Functional Micro-organization of Grid Cells Revealed by Cellular-Resolution Imaging. Heys JG, Rangarajan KV, and Dombeck DA. Neuron. 2014 December 3;84(5):1079-1090.

Widespread State-Dependent Shifts in Cerebellar Activity in Locomoting Mice. Ozden I, Dombeck DA, Hoogland TM, Tank DW, and Wang SS-H. PLoS ONE. 2012 August 3;7(8):e42650.

Real neuroscience in virtual worldsDombeck DA and Reiser MB. Current Opinion in Neurobiology. 2012 February;22(1):3-10.

Functional imaging of hippocampal place cells at cellular resolution during virtual navigationDombeck DA, Harvey CD, Tian L, Looger LL, and Tank DW. Nature Neuroscience. 2010 November;13(11):1433-1440.

Functional Clustering of Neurons in Motor Cortex Determined by Cellular Resolution Imaging in Awake Behaving MiceDombeck DA, Graziano MS, and Tank DW. Journal of Neuroscience. 2009 November 4;29(44):13751-13760.

Intracellular dynamics of hippocampal place cells during virtual navigation. Harvey CD, Collman F, Dombeck DA, and Tank DW. Nature. 2009 October 15;461(7266):941-946.

Imaging Large-Scale Neural Activity with Cellular Resolution in Awake, Mobile MiceDombeck DA, Khabbaz AN, Collman F, Adelman TL, and Tank DW. Neuron. 2007 October 4;56(1):43-57.

Overcoming photodamage in second-harmonic generation microscopy: Real-time optical recording of neuronal action potentials. Sacconi L, Dombeck DA, and Webb WW. PNAS. 2006 February 28;103(9):3124-3129.

Optical Recording of Fast Neuronal Membrane Potential Transients in Acute Mammalian Brain Slices by Second-Harmonic Generation MicroscopyDombeck DA, Sacconi L, Blanchard-Desce M, and Webb WW. Journal of Neurophysiology. 2005 November 1;94(5):3628-3636.

View all publications by Daniel A. Dombeck listed in the National Library of Medicine (PubMed).