Karl A. Scheidt Professor of Chemistry

Research Interests

Our Research Focuses on These Complementary Areas: Drug Discovery, Bioorganic Chemistry, and Small Molecule-Driven Chemical Biology.

We are particularly interested in designing novel methods and strategies for the construction of complex natural products with important biological attributes. Our methodology programs encompass assembling molecules and introducing stereogenic centers using new catalytic reactions. 

Selected Publications

Virtual High-Throughput Screening to Identify Novel Activin Antagonists. Zhu J, Mishra RK, Schiltz GE, Makanji Y, Scheidt KA, Mazar AP, and Woodruff TK. Journal of Medicinal Chemistry. 2015 July 23;58(14):5637-5648.

Enantioselective Syntheses of Heteroyohimbine Natural Products: A Unified Approach through Cooperative Catalysis. Younai A, Zeng B-S, Meltzer HY, and Scheidt KA. Angewandte Chemie. 2015 June 1;54(23):6900-6904.

Enantioselective β-Protonation by a Cooperative Catalysis Strategy. Wang MH, Cohen DT, Schwamb CB, Mishra RK, and ScheidtKA. Journal of the American Chemical Society. 2015 May 13;137(18):5891-5894.

Cooperative Catalysis of Cyclic Carbonate Ring Opening: Application towards Non-Isocyanate Polyurethane Materials. Lombardo VM, Dhulst EA, Leitsch EK, Wilmot N, Heath WH, Gies AP, Miller MD, Torkelson JM, and Scheidt KA. European Journal of Organic Chemistry. 2015 May;2015(13):2791-2795.

Pyranone Natural Products as Inspirations for Catalytic Reaction Discovery and Development. McDonald BR and Scheidt KA.Accounts of Chemical Research. 2015 April 21;48(4):1172-1183.

Ferrocene-Based Planar Chiral Imidazopyridinium Salts for Catalysis. Check CT, Jang KP, Schwamb CB, Wong AS, Wang MH, andScheidt KA. Angewandte Chemie. 2015 March 27;54(14):4264-4268.

N-Heterocyclic carbene-catalyzed enantioselective annulations: a dual activation strategy for a formal [4+2] addition for dihydrocoumarins. Lee A and Scheidt KA. Chemical Communications. 2015 February 25;51(16):3407-3410.

Functionalized cyclopentenes through a tandem NHC-catalyzed dynamic kinetic resolution and ambient temperature decarboxylation: mechanistic insight and synthetic application. Cohen DT, Johnston RC, Rosson NT, Cheong PH, and ScheidtKA. Chemical Communications. 2015 February 14;51(13):2690-2693.

A Biomimetic Strategy to Access the Silybins: Total Synthesis of (−)-Isosilybin A. McDonald BR, Nibbs AE, and Scheidt KA.Organic Letters. 2015 January 2;17(1):98-101.

A cooperative N-heterocyclic carbene/palladium catalysis system. Liu K, Hovey MT, and Scheidt KA. Chemical Science. 2014 October 1;5(10):4026-4031.

View all publications by Karl A. Scheidt listed in the National Library of Medicine (PubMed).