Richard Carthew Owen L. Coon Professor of Molecular Biosciences

Research Interests

Quantitative and Systems Biology

Our group studies how complex cell and tissue behaviors are elicited within the context of the organism. We work as experimentalists, teaming up with theorists in applied mathematics, physics, and engineering, to apply systematic and quantitative approaches to biological problems. Gene regulation is of particular interest, and we have a long-standing interest in why non-coding RNAs regulate gene expression.

The irreversible transition of cells to a differentiated state is a continual process throughout life. Although the signaling and regulatory molecules required for many differentiation processes are known, they alone do not explain this emergent property of animal cells. We apply quantitative methods to the problem, and consider all manner of cues received by cells, including those of a biochemical or mechanical nature.The irreversible transition of cells to a differentiated state is a continual process throughout life. Although the signaling and regulatory molecules required for many differentiation processes are known, they alone do not explain this emergent property of animal cells. We apply quantitative methods to the problem, and consider all manner of cues received by cells, including those of a biochemical or mechanical nature.

Selected Publications

MicroRNA function in Drosophila melanogaster. Carthew RW, Agbu P, and Giri R. Seminars in Cell & Developmental Biology. 2017 May;65:29-37.

MicroRNAs Make a Difference in Cardiovascular Robustness. Bakker R and Carthew RW. Developmental Cell. 2017 March 27;40(6):515-516.

Hexagonal Patterning of the Insect Compound Eye: Facet Area Variation, Defects, and Disorder. Kim S, Cassidy JJ, Yang B, Carthew RW, and Hilgenfeldt S. Biophysical Journal. 2016 December 20;111(12):2735-2746.

Spindle-E cycling between nuage and cytoplasm is controlled by Qin and PIWI proteinsAndress A, Bei Y, Fonslow BR, Giri R, Wu Y, Yates JR, and Carthew RW. Journal of Cell Biology. 2016 April 25;213(2):201-211.

Differential Masking of Natural Genetic Variation by miR-9a in DrosophilaCassidy JJ, Straughan AJ, and Carthew RW. Genetics. 2016 February;202(2):675-687.

Dynamics and heterogeneity of a fate determinant during transition towards cell differentiationPeláez N, Gavalda-Miralles A, Wang B, Tejedor Navarro H, Gudjonson H, Rebay I, Dinner AR, Katsaggelos AK, Amaral LAN, and Carthew RW. eLife. 2015 November 19;4:e08924.

A comparative study of Pointed and Yan expression reveals new complexity to the transcriptional networks downstream of receptor tyrosine kinase signaling. Boisclair Lachance J-F, Peláez N, Cassidy JJ, Webber JL, Rebay I, and Carthew RW. Developmental Biology. 2014 January 15;385(2):263-278.

miR-9a Minimizes the Phenotypic Impact of Genomic Diversity by Buffering a Transcription FactorCassidy JJ, Jha AR, Posadas DM, Giri R, Venken KJT, Ji J, Jiang H, Bellen HJ, White KP, and Carthew RW. Cell. 2013 December 19;155(7):1556-1567.

Functionally Diverse MicroRNA Effector Complexes Are Regulated by Extracellular SignalingWu P-H, Isaji M, and Carthew RW. Molecular Cell. 2013 October 10;52(1):113-123.

Functional Specialization of the Small Interfering RNA Pathway in Response to Virus Infection. Marques JT, Wang J-P, Wang X, de Oliveira KPV, Gao C, Aguiar ERGR, Jafari N, and Carthew RW. PLoS Pathogens. 2013 August 29;9(8):e1003579.

View all publications by Richard Carthew listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.