Teri Odom Charles E. and Emma H. Morrison Professor of Chemistry

Research Interests

Controlling the size and shape of noble metals at the nanoscale

Our group focuses on “making precious metals more precious” by controlling the size and shape of noble metals at the nanoscale. Our strategies include the development of new nanofabrication tools to create three-dimensional architectures with structural function that can span three orders of magnitude simultaneously. We are also pursuing simple and scalable approaches to synthesize anisotropic particles. To understand the details of how light interacts with these structures, we use modeling to calculate the optical properties of single particles as well as the collective effects of assemblies of nanoparticles. Applications of these unique materials include nanomedicine, photovoltaics, sensing, and imaging.

Nanomedicine and Bioimaging. Direct visualization of interactions between drug-loaded nanoparticles and the cancer cell nucleus is crucial for understanding how to improve the efficacy of therapeutics. We have recently designed nanoconstructs composed of nucleolin-specific aptamers and gold nanostars that not only can target cancer cells but can be actively transported to the nucleus and then induce major changes in nuclear phenotype. We are developing these nanoconstructs as a new type of drug delivery system since their “cargo” can be released using ultra-fast, laser light. Also, we are interested in probing how nanoparticles behave intracellularly and are focusing on uptake and transport mechanisms.

Nanophotonics and Nano-optics. Coherent light sources at the nanoscale are important for investigating phenomena in small dimensions and for realizing optical devices with sizes that can beat the diffraction limit of light. Plasmonic lasers can have sub-wavelength sizes because they exploit surface plasmons which have strongly confined electromagnetic fields. We are interested in designing laser devices based on coupled plasmonic nanoparticles and that are the size of a virus particle. In addition, we are designing new types of metal lenses based on a metamaterial concept with properties not possible in conventional lenses.

Materials and Nanofabrication. One important challenge in nanoscience is the development of innovative tools that can manipulate nanoscale building blocks into hierarchical structures over large areas. This control requires a detailed understanding over several length scales in order to achieve (1) precise nanoscale (1-100 nm) manipulation and (2) assembly into mesoscale (100-1000 nm) structures. We are working on many different materials systems, including patterning liquid metals to achieve switchable optical properties, creating nanowrinkles in polymer films based on chemical treatment of the surface, and inventing new lithographies such as moiré nanolithography that can result in high-order rotational symmetry lattices.

Selected Publications

Gold Nanoparticle Size and Shape Effects on Cellular Uptake and Intracellular Distribution of siRNA Nanoconstructs. Yue J, Feliciano TJ, Li W, Lee A, and Odom TW. Bioconjugate Chemistry. 2017 June 21;28(6):1791-1800.

Stretchable Superhydrophobicity from Monolithic, Three-Dimensional Hierarchical Wrinkles. Lee W-K, Jung W-B, Nagel SR, and Odom TW. Nano Letters. 2016 June 8;16(6):3774-3779.

Unidirectional Lasing from Template-Stripped Two-Dimensional Plasmonic Crystals. Yang A, Li Z, Knudson MP, Hryn AJ, Wang W, Aydin K, and Odom TW. ACS Nano. 2015 December 22;9(12):11582-11588.

Shape-Dependent Nonlinear Optical Properties of Anisotropic Gold Nanoparticles. Hua Y, Chandra K, Dam DHM, Wiederrecht GP, and Odom TW. Journal of Physical Chemistry Letters. 2015 December 17;6(24):4904-4908.

Enhanced Human Epidermal Growth Factor Receptor 2 Degradation in Breast Cancer Cells by Lysosome-Targeting Gold Nanoconstructs. Lee H, Dam DHM, Ha JW, Yue J, and Odom TW. ACS Nano. 2015 October 27;9(10):9859-9867.

Controlled Three-Dimensional Hierarchical Structuring by Memory-Based, Sequential Wrinkling. Lee W-K, Engel CJ, Huntington MD, Hu J, and Odom TW. Nano Letters. 2015 August 12;15(8):5624-5629.

Real-time tunable lasing from plasmonic nanocavity arrays. Yang A, Hoang TB, Dridi M, Deeb C, Mikkelsen MH, Schatz GC, and Odom TW. Nature Communications. 2015 April 20;6:6939.

Biodistribution and in vivo toxicity of aptamer-loaded gold nanostars. Dam DHM, Culver KSB, Kandela I, Lee RC, Chandra K, Lee H, Mantis C, Ugolkov A, Mazar AP, and Odom TW. Nanomedicine. 2015 April;11(3):671-679.

High Relaxivity Gd(III)-DNA Gold Nanostars: Investigation of Shape Effects on Proton Relaxation. Rotz MW, Culver KSB, Parigi G, MacRenaris KW, Luchinat C, Odom TW, and Meade TJ. ACS Nano. 2015 March 24;9(3):3385-3396.

Tunable Loading of Oligonucleotides with Secondary Structure on Gold Nanoparticles through a pH-Driven Method. Dam DHM, Lee H, Lee RC, Kim KH, Kelleher NL, and Odom TW. Bioconjugate Chemistry.2015 February 18;26(2):279-285.

Subwavelength Lattice Optics by Evolutionary Design. Huntington MD, Lauhon LJ, and Odom TW. Nano Letters. 2014 December 10;14(12):7195-7200.

View all publications by Teri W. Odom in the National Library of Medicine (PubMed). Current and former IBiS students in blue.