Vadim Backman Walter Dill Scott Professor of Biomedical Engineering

Research Interests

The main direction of our lab is the development of novel optical spectral and imaging techniques for non-invasive screening, diagnosis and detection of disease, and characterization of biological and bioengineered tissue. Our research spans from basic physics of light-tissue interaction to new technology development to the development of clinical instrumentation and to large-scale clinical trials.

Selected Publications

The Global Relationship between Chromatin Physical Topology, Fractal Structure, and Gene ExpressionAlmassalha LM, Tiwari A, Ruhoff PT, Stypula-Cyrus Y, Cherkezyan L, Matsuda H, Dela Cruz MA, Chandler JE, White C, Maneval C, Subramanian H, Szleifer I, Roy HK, and Backman V. Scientific Reports. 2017 January 24;7:41061.

Label-free imaging of the native, living cellular nanoarchitecture using partial-wave spectroscopic microscopyAlmassalha LM, Bauer GM, Chandler JE, Gladstein S, Cherkezyan L, Stypula-Cyrus Y, Weinberg S, Zhang D, Ruhoff PT, Roy HK, Subramanian H, Chandel NS, Szleifer I, and Backman V. PNAS. 2016 October 18;113(42):E6372-E6381.

Detection of extracellular matrix modification in cancer models with inverse spectroscopic optical coherence tomography. Spicer GLC, Azarin SM, Yi J, Young ST, Ellis R, Bauer GM, Shea LD, and Backman V. Physics in Medicine and Biology. 2016 October 7;61(19):6892-6904.

Enhanced Survival with Implantable Scaffolds That Capture Metastatic Breast Cancer Cells In Vivo. Rao SS, Bushnell GG, Azarin SM, Spicer G, Aguado BA, Stoehr JR, Jiang EJ, Backman V, Shea LD, and Jeruss JS. Cancer Research. 2016 September 15;76(18):5209-5218.

Superresolution intrinsic fluorescence imaging of chromatin utilizing native, unmodified nucleic acids for contrast. Dong B, Almassalha LM, Stypula-Cyrus Y, Urban BE, Chandler JE, Nguyen T-Q, Sun C, Zhang HF, and Backman V. PNAS. 2016 August 30;113(35):9716-9721.

Super-resolution spectroscopic microscopy via photon localization. Dong B, Almassalha L, Urban BE, Nguyen T-Q, Khuon S, Chew T-L, Backman V, Sun C, and Zhang HF. Nature Communications. 2016 July 25;7:12290.

Subsurface Super-resolution Imaging of Unstained Polymer Nanostructures. Urban BE, Dong B, Nguyen T-Q, Backman V, Sun C, and Zhang HF. Scientific Reports. 2016 June 29;6:28156.

Finite-difference time-domain-based optical microscopy simulation of dispersive media facilitates the development of optical imaging techniques. Zhang D, Capoglu I, Li Y, Cherkezyan L, Chandler J, Spicer G, Subramanian H, Taflove A, and Backman V. Journal of Biomedical Optics. 2016 June 10;21(6):065004.

Skeletal light-scattering accelerates bleaching response in reef-building corals. Swain TD, DuBois E, Gomes A, Stoyneva VP, Radosevich AJ, Henss J, Wagner ME, Derbas J, Grooms HW, Velazquez EM, Traub J, Kennedy BJ, Grigorescu AA, Westneat MW, Sanborn K, Levine S, Schick M, Parsons G, Biggs BC, Rogers JD, Backman V, and Marcelino LA. BMC Ecology. 2016 March 21;16:10.

Nanoscale refractive index fluctuations detected via sparse spectral microscopy. Chandler JE, Cherkezyan L, Subramanian H, and Backman V. Biomedical Optics Express. 2016 March 1;7(3):883-893.

View all publications by Vadim Backman listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.