Xiaozhong (Alec) Wang Associate Professor of Molecular Biosciences

Research Interests

The Wang lab uses genomics approaches to investigate regulatory pathways in mammalian stem cells.  Using mouse embryonic stem cells as a model system, our general experimental approach is to gain mechanistic insights by constructing both genetic interaction and protein-protein interaction maps of a key regulatory network.  We are currently working on two projects. First, we are investigating how nucleosomes encode epigenetic information to influence gene expression using a chemical biology approach.  Second, we are interested in how RNA repair pathways control cellular stress responses.

Selected Publications

Genome-wide Mapping of the Nucleosome Landscape by Micrococcal Nuclease and Chemical Mapping. Voong LN, Xi L, Wang J-P, and Wang X. Trends in Genetics. 2017 August;33(8):495-507.

Insights into Nucleosome Organization in Mouse Embryonic Stem Cells through Chemical Mapping. Voong LN, Xi L, Sebeson AC, Xiong B, Wang J-P, and Wang X. Cell. 2016 December 1;167(6):1555-1570.

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB. Lu Y, Liang F-X, and Wang X. Molecular Cell. 2014 September 4;55(5):758-770.

Mammalian hyperplastic discs Homolog EDD Regulates miRNA-Mediated Gene Silencing. Su H, Meng S, Lu Y, Trombly MI, Chen J, Lin C, Turk A, and Wang X. Molecular Cell. 2011 July 8;43(1):97-109.

Essential and overlapping functions for mammalian Argonautes in microRNA silencing. Su H, Trombly MI, Chen J, and Wang X. Genes & Development. 2009 February 1;23(3):304-317.

View all publications by Xiaozhong Wang listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.