Yevgenia Kozorovitskiy Development, modulation, and functions of neurons and their synapses

Research Interests

The long-range goal of our lab is to accelerate the understanding of neuromodulation and plasticity in the vertebrate brain. Our studies will facilitate the development of therapeutic applications, harnessing the power of neuromodulators to functionally reconfigure, and sometimes even literally rewire, neural circuits.

Neuromodulation is biologically complex, requiring a diverse set of tools. We rely on 2-photon imaging and 2-photon neurotransmitter photorelease, whole-cell electrophysiology, electron microscopy, neuroproteomics, opto- and pharmacogenetics, neuroanatomical, transcriptional and behavioral analyses. We also work to develop and refine new optical imaging and synthetic biology techniques.

Selected Publications

Integrated one- and two-photon scanned oblique plane illumination (SOPi) microscopy for rapid volumetric imaging. Kumar M, Kishore S, Nasenbeny J, McLean DL, and Kozorovitskiy Y. Optics Express. 2018 May 14;26(10):13027-13041.

Photoactivatable drugs for nicotinic optopharmacology. Banala S, Arvin MC, Bannon NM, Jin X-T, Macklin JJ, Wang Y, Peng C, Zhao G, Marshall JJ, Gee KR, Wokosin DL, Kim VJ, McIntosh JM, Contractor A, Lester HA, Kozorovitskiy Y, Drenan RM, and Lavis LD. Nature Methods. 2018 May;15(5):347-350.

Oxytocin functions as a spatiotemporal filter for excitatory synaptic inputs to VTA dopamine neurons. Xiao L, Priest MF, and Kozorovitskiy Y. eLife. 2018 April 20;7:e33892.

Imaging neuronal structure dynamics using 2‐photon super‐resolution patterned excitation reconstruction microscopy. Urban BE, Xiao L, Dong B, Chen S, Kozorovitskiy Y, and Zhang HF. Journal of Biophotonics. 2018 March;11(3):e201700171.

In Vivo Superresolution Imaging of Neuronal Structure in the Mouse Brain. Urban BE, Xiao L, Chen S, Yang H, Dong B, Kozorovitskiy Y, and Zhang HF. IEEE Transactions on Biomedical Engineering. 2018 January;65(1):232-238.

Biased Oxytocinergic Modulation of Midbrain Dopamine Systems. Xiao L, Priest MF, Nasenbeny J, Lu T, and Kozorovitskiy Y. Neuron. 2017 July 19;95(2):368-384.e5.

View all publications by Yevgenia Kozorovitskiy listed in the National Library of Medicine (PubMed).