David L. McLean Development and plasticity of motor networks

Research Interests

Repetitive movements, like walking or breathing, are generated by networks of rhythmically active neurons. We are interested in how rhythmic networks develop and produce movements of different speeds and intensities. To do this, we study the spinal networks controlling innate motor behaviors in developing zebrafish. Zebrafish provide a unique opportunity to combine imaging, electrophysiological and molecular approaches to examine the neural control of behavior in the living organism. By revealing common principles of organization, we hope to provide insights into disorders that affect our capacity to move, like Parkinson’s disease, epilepsy or spinal injury.

Selected Publications

Neuromodulation: Letting Sources of Spinal Dopamine Speak for Themselves. Kishore S and McLean DL. Current Biology. 2015 February 16;25(4):R146-R148.

Systematic Shifts in the Balance of Excitation and Inhibition Coordinate the Activity of Axial Motor Pools at Different Speeds of Locomotion. Kishore S, Bagnall MW, and McLean DL. Journal of Neuroscience. 2014 October 15;34(42):14046-14054.

Selective Responses to Tonic Descending Commands by Temporal Summation in a Spinal Motor Pool. Wang W-C and McLean DL. Neuron. 2014 August 6;83(3):708-721.

Differences in the morphology of spinal V2a neurons reflect their recruitment order during swimming in larval zebrafish. Menelaou E, VanDunk C, and McLean DL. Journal of Comparative Neurology. 2014 April 15;522(6):1232-1248.

Modular Organization of Axial Microcircuits in Zebrafish. Bagnall MW and McLean DL. Science. 2014 January 10;343(6167):197-200.

View all publications by David L. McLean listed in the National Library of Medicine (PubMed).