Thomas J. Meade Bioinorganic coordination chemistry, biological molecular imaging, transcription factor inhibitors, electronic biosensors

Research Interests

The Meade Lab research focuses on inorganic coordination chemistry for the study of molecular imaging of in vivo gene expression and intracellular messengers, transition metal enzyme inhibitors, and electronic biosensors. The design, synthesis and physical properties of transition metal and lanthanide coordination complexes are the foundation of our research.

Selected Publications

Gd(III)–Pt(IV) theranostic contrast agents for tandem MR imaging and chemotherapy. Adams CJ and Meade TJ. Chemical Science. 2020 March 7;11(9):2524-2530.

A Multimodal Ca(II) Responsive Near IR-MR Contrast Agent Exhibiting High Cellular Uptake. Adams CJ, Krueger R, and Meade TJ. ACS Chemical Biology. 2020 February 21;15(2):334-341.

Self‐Immolative Activation of β‐Galactosidase‐Responsive Probes for In Vivo MR Imaging in Mouse Models. Lilley LM, Kamper S, Caldwell M, Chia ZK, Ballweg D, Vistain L, Krimmel J, Mills TA, MacRenaris K, Lee P, Waters EA, and Meade TJ. Angewandte Chemie Int Ed. 2020 January 2;59(1):388-394.

Water-Soluble Nanoconjugate for Enhanced Cellular Delivery of Receptor-Targeted Magnetic Resonance Contrast Agents. Moore LK, Caldwell MA, Townsend TR, MacRenaris KW, Moyle-Heyrman G, Rammohan N, Schonher EK, Burdette JE, Ho D, and Meade TJ. Bioconjugate Chemistry. 2019 November 20;30(11):2947-2957.

Inhibition of Amyloid-β Aggregation by Cobalt(III) Schiff Base Complexes: A Computational and Experimental Approach. Iscen A, Brue CR, Roberts KF, Kim J, Schatz GC, and Meade TJ. Journal of the American Chemical Society. 2019 October 23;141(42):16685-16695.

View all publications by Thomas J. Meade listed in the National Library of Medicine (PubMed). Current and former IBiS students in blue.