Richard I. Morimoto Cell stress responses, molecular chaperones, protein conformational disease

Research Interests

Over the past 150 years, human lifespan has doubled. While the benefits of longevity are immeasurable, this benefit is also accompanied by the increased risk for age-associated diseases including cancer, muscle wasting diseases, dementia and neurodegeneration. Because aging and degenerative diseases have a causal relationship and are associated with increased molecular and cellular damage, this has led to questions on the basis and timing of molecular failure, and efforts to identify the genetic pathways that regulate the functional health of the cellular proteome, and to develop small molecule therapeutic approaches targeted to specific pathways of the proteostasis network to alter the course of this decline.

Selected Publications

Tau protein aggregates inhibit the protein-folding and vesicular trafficking arms of the cellular proteostasis network. Yu A, Fox SG, Cavallini A, Kerridge C, O'Neill MJ, Wolak J, Bose S, and Morimoto RI. Journal of Biological Chemistry. 2019 May 10;294(19):7917-7930.

Cell-Nonautonomous Regulation of Proteostasis in Aging and Disease. Morimoto RI. Cold Spring Harbor Perspectives in Biology. 2019 April 8:epub before print.

Mitochondrial Stress Restores the Heat Shock Response and Prevents Proteostasis Collapse during Aging. Labbadia J, Brielmann RM, Neto MF, Lin Y-F, Haynes CM, and Morimoto RI. Cell Reports. 2017 November 7;21(6):1481-1494.

E2F coregulates an essential HSF developmental program that is distinct from the heat-shock response. Li J, Chauve L, Phelps G, Brielmann RM, and Morimoto RI. Genes & Development. 2016 September 15;30(18):2062-2075

Repression of the Heat Shock Response Is a Programmed Event at the Onset of Reproduction. Labbadia J and Morimoto RI. Molecular Cell. 2015 August 20;59(4):639-650. 

View all publications by Richard I. Morimoto listed in the National Library of Medicine (PubMed).